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投稿过纯生信的小伙伴肯定遇到过审稿人 要求补充验证实验 的问题，甚至一次修回3个审稿人每个人都要求补充实验。 Comment 1： It would be important to validate the results either using larger sample size or using bootstrapping or resampling to estimate the stability and reliability of the results. Comment 2： The results described were obtained by the second-use of the data published by another group. The second use itself is OK, but analyses are quite superficial, and no experimental validation (gene expression as well as potential usabilities of identified differentially expressed genes for vaccine development) was done. Comment 3： This is a study based purely on bioinformatics analysis. There are no convincing validation studies from clinical patients samples or experimental studies. The authors need to add more validation studies to support their conclusions. Comment 4： The biggest limitation of this study is that no laborator
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