GPR34是ILC1介导的抗肿瘤免疫的代谢免疫检查点

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SCI 1 November 2024 GPR34 is a metabolic immune checkpoint for ILC1-mediated antitumor immunity (Nature Immunology, IF: 27.7) Jiaxian Yan, Chi Zhang, Yueli Xu, Zonghui Huang, Qingyuan Ye, Xiaojun Qian, Liang Zhu, Guangming Huang, Xiaqiong Wang, Wei Jiang & Rongbin Zhou CORRESPONDENCE TO: wxq1989@ustc.edu.cn; ustcjw@ustc.edu.cn; zrb1980@ustc.edu.cn Type 1 innate lymphoid cells (ILC1s) are a class of tissue-resident cells with antitumor activity, suggesting its possible role in solid tumor immune surveillance, but it is not clear whether manipulating ILC1s can induce potent antitumor immune responses. Here, we found that G-protein-coupled receptor 34 (GPR34), a receptor for lysophosphatidylserine (LysoPS), was highly expressed on ILC1s but not on conventional natural killer cells in the tumor microenvironment. LysoPS was enriched in the tumor microenvironment and could inhibit ILC1 activation via GPR34. Genetic deletion of LysoPS synthase Abhd16a expression in tumors or Gpr34 expressio ………………………………