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Digital Twin Ecosystems Engineering & Applications Submission DeadLine: 20 May 2025 Motivation and Scope Recent advances in the areas of the Internet of Things, Artificial Intelligence, and Big Data Analytics have accelerated the use of Digital Twins to engineer cyber-physical systems in a range of diverse application domains such as manufacturing, healthcare, farming, and smart cities. Digital Twins are virtual replicas of physical entities supported by real-time sensory inputs, and advanced data processing to create and feed complex digital models. Continuous monitoring, analysis, prediction and simulation of the real-world counterparts are among the main capabilities of Digital Twins, enhancing decision-making, efficiency, and proactive maintenance. When applied to large-scale scenarios, where monolithic solutions are not feasible, integrated networks of Digital Twins are being proposed as a modelling tool to offer a comprehensive view of a domain leading to the concept of Digital
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