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SCI 30 J uly 2024 Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment (Nature Reviews Cancer, IF: 72.5) Roel Polak, Elisa T. Zhang & Calvin J. Kuo CORRESPONDENCE TO：cjkuo@stanford.edu Abstract 摘要 The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME). Cancer immunotherapies targeting the immune TME have been increasingly validated in clinical trials but response rates vary substantially between tumour histologies and are often transient, idiosyncratic and confounded by resistance. Faithful experimental models of the patient-specific tumour immune microenvironment, capable of recapitulating tumour biology and immunotherapy effects, would greatly improve patient selection, target identification and definition of resistance mechanisms for immuno-oncology therapeutics. In this Review, we discuss currently available and rapidly evolving 3D tumour organoid
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