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综述的主要目的和意义 本文是一篇关于天然产物抗生素领域的综述,在2024年7月31日在线发表于Nature。 作者希望通过回顾一些具有复杂作用机制的天然产物抗生素,为开发急需的新型抗菌药物提供启示。这些天然产物展现了多样化的抗菌策略,包括共价结合、抗耐药、自我促进进入细胞、逃避耐药、前药、破坏靶标、抑制"无法成药"的靶点、形成超分子复合物以及选择性作用于膜等。 In this Review, we explore natural product antibiotics that do more than simply inhibit an active site of an essential enzyme. We review these compounds to provide inspiration for the design of much-needed new antibacterial agents, and examine the complex mechanisms that have evolved to effectively target bacteria, including covalent binders, inhibitors of resistance, compounds that utilize self-promoted entry, those that evade resistance, prodrugs, target corrupters, inhibitors of 'undrugga
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