糖鞘脂合成介导KRAS驱动癌症中的免疫逃逸

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SCI 1 September 2024 Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer (Nature, IF: 50.5) Mariluz Soula, Gokhan Unlu, Rachel Welch, Aleksey Chudnovskiy, Beste Uygur, Vyom Shah, Hanan Alwaseem, Paul Bunk, Vishvak Subramanyam, Hsi-Wen Yeh, Artem Khan, Søren Heissel, Hani Goodarzi5, Gabriel D. Victora, Semir Beyaz & Kıvanç Birsoy CORRESPONDENCE TO: kbirsoy@rockefeller.edu Cancer cells frequently alter their lipids to grow and adapt to their environment. Despite the critical functions of lipid metabolism in membrane physiology, signalling and energy production, how specific lipids contribute to tumorigenesis remains incompletely understood. Here, using functional genomics and lipidomic approaches, we identified de novo sphingolipid synthesis as an essential pathway for cancer immune evasion. Synthesis of sphingolipids is surprisingly dispensable for cancer cell proliferation in culture or in immunodeficient mice but required for tumour growth in multiple synge ………………………………