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本期导读 广西医科大学附属肿瘤医院/广西癌症中心梁嵘、林燕、叶甲舟团队首次揭示,在缺氧环境压力下,肝细胞癌(HCC)通过GP73促血管生成级联信号网络,与肿瘤血管内皮细胞互作诱导肝癌血管生成,进而促进HCC适应缺氧快速进展。研究成果以“Integrating Single-cell and Spatial Transcriptomics to uncover and elucidate a GP73-mediated Pro-angiogenic Regulatory Networks in Hepatocellular Carcinoma”为题发表在 Research 上。 Citation: Jiazhou Ye, Xing Gao, Xi Huang, Shilin Huang, Dandan Zeng, Wenfeng Luo, Rongyun Mai, Shan Wang, Yongqiang Li, Yan Lin, Rong Liang, et al. Integrating Single-cell and Spatial Transcriptomics to uncover and elucidate a GP73-mediated Pro-angiogenic Regulatory Networks in Hepatocellular Carcinoma. Research 2024; Article 0387. DOI: 10.34133/research.0387 研究背景 HCC具有高度血管化的生物学特征,其高效地为癌细胞输送氧气和营养,交换
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