专栏名称: Chestnut Studying
科研小屋,主要研究方向:炎症,先天免疫,组学
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Journal of Hepatology丨感染会长期改变库普弗细胞的表观基因组、转录组和功能

Chestnut Studying  · 公众号  ·  · 2024-08-14 09:23

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Chestnut Studying       摘要  Background and aims: Liver macrophages fulfill various homeostatic functions and represent an essential line of defense against pathogenic insults. However, it remains unclear whether a history of infectious disease in the liver instructs long-term alterations to the liver macrophage compartment. Methods:We utilized a curable model of parasitic infection invoked by the protozoan parasite Trypanosoma brucei brucei to investigate whether infection history can durably reshape hepatic macrophage identity and function. Employing a combination of fate mapping, single cell CITE-sequencing, single nuclei multiome analysis, epigenomic analysis, and functional assays, we studied the alterations to the liver macrophage compartment during and after the resolution of infection. Results:We show that T. b. brucei infection alters the composition of liver-resident macrophages, leading to the infiltration of monocytes that differentiate into various infection-associ ………………………………

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