骨生物学进展：化学诱导去分化生成可扩增的人类肢芽样祖细胞

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点击上方 蓝字 关注我们 Generation of human expandable limb-bud-like progenitors via chemically induced dedifferentiation 作者： Jialiang Zhu, Xinxing Zhong, Huanjing He, Jingxiao Cao, Zhengyang Zhou, Jiebin Dong, Honggang Li, Anqi Zhang, Yulin Lyu, Cheng Li, Jingyang Guan*, Hongkui Deng*. (MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences and MOE Engineering Research Center of Regenerative Medicine, School of Basic Medical Sciences, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.) 发表期刊： Cell Stem Cell . 2024 Oct 22. Doi：10.1016/j.stem.2024.10.001. 1 科学问题 自然界中，部分低等动物如蝾螈展现出卓越的再生能力，能够在损伤后完美修复重要组织器官，这归因于其体细胞的去分化潜能。然而，人类体细胞命运稳固、可塑性下降，导致再生能力 ………………………………