ROS响应性水凝胶负载miR-4500外泌体逆转肝纤维化

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研究内容简介 Schematic illustration of the fabrication and application of the ROS-responsive QCG@Exos m iR-4500 hydrogel in treating liver fibrosis. A) Preparation of the QCG@Exos miR-4500 hydrogel. B) Effective mechanisms of the QCG@Exos miR-4500 hydrogel: reversible boronic ester bonds were dissociated under the trigger of the local high ROS, releasing ExosmiR-4500 on demand, thus e xerting anti-oxidation, anti-angiogenesis, and anti-fibrosis effects. 肝纤维化是慢性肝病进展至肝硬化、肝癌等终末期肝病的关键事件，其逆转需要有效的策略减少氧化应激和抑制肝星状细胞（HSC）的激活。MiR-4500 能调节病理性血管生成和胶原mRNA稳定性，具有抑制纤维化的潜力。外泌体（Exos）是miRNA的天然转运载体，具有非免疫原性和高安全性等优点。然而，Exos的临床应用必须克服稳定性差和保留率低的问题。本研究通过季铵化壳聚糖和4-羧基苯硼酸改性明胶的动态交 ………………………………