主要观点总结
本文重点探讨了癌症如何通过系统性改变远端器官环境来促进癌细胞的转移与生长，主要分析了肿瘤诱导的“前转移微环境”（PMN）的形成机制和其在转移过程中的重要性。
关键观点总结
关键观点1: 背景与重要性
文章阐述了癌症与宿主系统的整合，以及前转移微环境（PMN）在转移过程中的关键作用。
关键观点2: 肿瘤诱导的系统性条件反应
癌细胞通过分泌外泌体和其他因子，引发远端组织的变化，为转移细胞的生长创造有利环境。
关键观点3: 主要效应器与机制
文章详细描述了外泌体、可溶性因子、成纤维细胞和间质细胞以及免疫细胞在癌症诱导的远端器官改变中的作用。
关键观点4: 系统性通信与远端器官响应
文章讨论了癌症如何通过系统性改变影响多个器官系统的生理平衡，以及多器官之间的相互作用。
关键观点5: 临床前景与未来方向
文章指出，理解PMN的形成机制有助于开发新的预防和治疗策略，同时强调了未来研究面临的挑战和潜力。
文章预览
SCI 19 November 2024 Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells (IF: Nat Rev Cancer., 72.5) Rabas N, Ferreira RMM, Di Blasio S, Malanchi I. Cancer-induced systemic pre-conditioning of distant organs: building a niche for metastatic cells. Nat Rev Cancer. 2024 Oct 10. Correspondence: e-mail: Ilaria.Malanchi@crick.ac.uk From their early genesis, tumour cells integrate with the surrounding normal cells to form an abnormal structure that is tightly integrated with the host organism via blood and lymphatic vessels and even neural associations. Using these connections, emerging cancers send a plethora of mediators that efficiently perturb the entire organism and induce changes in distant tissues. These perturbations serendipitously favour early metastatic establishment by promoting a more favourable tissue environment (niche) that supports the persistence of disseminated tumour cells within a foreign tissue. Because the establishment
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