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SCI 30 October 2024 Spatial oncology: Translating contextual biology to the clinic (Cancer Cell, IF: 48.8) Dennis Gong, Jeanna M. Arbesfeld-Qiu, Ella Perrault, Jung Woo Bae, and William L. Hwang CORRESPONDENCE TO: whwang1@mgh.harvard.edu SUMMARY 摘要 Microscopic examination of cells in their tissue context has been the driving force behind diagnostic histopathology over the past two centuries. Recently, the rise of advanced molecular biomarkers identified through single cell profiling has increased our understanding of cellular heterogeneity in cancer but have yet to significantly impact clinical care. Spatial technologies integrating molecular profiling with microenvironmental features are poised to bridge this translational gap by providing critical in situ context for understanding cellular interactions and organization. Here, we review how spatial tools have been used to study tumor ecosystems and their clinical applications. We detail findings in cell-cell interactions, micro
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