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三代测序探索者每周文献精选 （09.30-10.13 ） 01 The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution 杂志：Nature（IF=50.5） 发表时间：2024.10.09 第一作者：Duy D. Nguyen（Weill Cornell Medicine） 通讯作者：Bishoy M. Faltas（Weill Cornell Medicine） 原文链接：https://www.nature.com/articles/s41586-024-07955-3 解读链接： https://mp.weixin.qq.com/s/ClrB5DHXgrIB0DzYJY0f_A Figure1.The interplay between APOBEC3 and platinum chemotherapy-induced mutagenesis and ecDNA during UC evolution. 亮点： In the paper,we discovered that most CCND1 amplifications in urothelial cancer arise within circular ecDNA-forming SVs. ecDNA-forming SVs persisted and increased in complexity,incorporating additional DNA segments and contributing to the evolution of treatment resistance. Oxford Nanopore Technologies long-read whole-genome sequencing followed by de novo assembly mapped out CCND1 ecDNA structure. 02 A potent pan-sarbecovirus n
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