三代测序探索者每周文献精选（09.09-09.22）

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三代测序探索者每周文献精选 （09.09-09.22 ） 01 Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2 杂志：Signal transduction and targeted therapy（IF=40.8） 发表时间：2024.9.18 第一作者：Miao Zhu（Center for Emerging Infectious Diseases, Wuhan Institute of Virology） 通讯作者：Wuxiang Guan（Center for Emerging Infectious Diseases, Wuhan Institute of Virology） 原文链接：https://www.nature.com/articles/s41392-024-01956-4 Fig1.SARS-CoV-2 infection decreases ACTN4 expression in an epitranscriptomic manner. 亮点： In the current study, the interplay between the host factors and viral proteins were analyzed by combined nanopore high-throughput sequencing and second-generation sequencing. The host factor ACTN4 was found to interact with viral RdRp, which impeded viral replication. Notably, two ACTN4 agonists were capable of inhibiting the replication of various SARS-CoV-2 strains both in vitro and in vivo. The results show ………………………………