Journal of Medicinal Chemistry，2024年67卷11期先导化合物

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VHH Nanobody Versatility against Pentameric Ligand-Gated Ion Channels Emerging Targets and Therapeutics in Immuno-Oncology: Insights from Landscape Analysis Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit  KRAS  Mutant Cancer Cell Growth Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε Rigid Fe(III) Chelate with Phosphonate Pendants: A Stable and Effective Extracellular MRI Contrast Agent Explorations of Agonist Selectivity for the α9* nAChR with Novel Substituted Carbamoyl/Amido/Heteroaryl Dialkylpiperazinium Salts and Their Therapeutic Implications in Pain and Inflammation Discovery of Novel Dual Inhibitors Targeting Mutant IDH1 and NAMPT for the Treatment of Glioma with IDH1Mu ………………………………