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发现microRNA及其转录后基因调控功能 (https://x.com/NobelPrize) Victor R. Ambros (born 1953, Hanover, New Hampshire ) is an American developmental biologist who discovered the first known microRNA (miRNA). He is a professor at the University of Massachusetts Medical School in Worcester , Massachusetts . Gary Bruce Ruvkun (born March 1952, Berkeley, California ) [ 1 ] is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston . [ 2 ] Ruvkun discovered the mechanism by which lin-4 , the first microRNA (miRNA) discovered by Victor Ambros , regulates the translation of target messenger RNAs via imperfect base-pairing to those targets, and discovered the second miRNA, let-7 , and that it is conserved across animal phylogeny, including in humans. These miRNA discoveries revealed a new world of RNA regulation at an unprecedented small size scale, and th
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