PD-1 表达的表观遗传调节可改善耗竭的 T 细胞功能和病毒控制

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SCI 9 October 2024 Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control （IF: Nat Immunol., 27.7） Weiss SA, Huang AY, Fung ME, Martinez D, Chen ACY, LaSalle TJ, Miller BC, Scharer CD, Hegde M, Nguyen TH, Rowe JH, Osborn JF, Patterson DG, Sifnugel N, Mei-An Nolan C, Davidson RA, Schwartz MA, Bally APR, Neeld DK, LaFleur MW, Boss JM, Doench JG, Nicholas Haining W, Sharpe AH, Sen DR. Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control. Nat Immunol. 2024 Oct;25(10):1871-1883.  Correspondence:  arlene_sharpe@hms.harvard.edu; dsen@mgh.harvard.edu PD-1 is a key negative regulator of CD8+ T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1 blockade can improve viral and tumor control, physiological PD-1 expression prevents immunopathology and improves memory formation. The mechanisms driving high PD-1 expression in exhaustion are not well understood an ………………………………