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Org. Lett., 2000, 2, 2339–2341. DOI: 10.1021/ol006097b ◆ Merck have reported α -aryl ketones to react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines. ◆ The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the β -position (R’’). ◆ The reaction was applied to the preparationof the COX-2 inhibitor as well as that of a series of analogues. ◆ In a separate publication the group describe the preparation of the vinamidinium species. The hexafluorophosphate salts are easily handled and provide an alternative to the more commonly used perchlorate and chloride salts of organic cations.
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