肿瘤微环境中的氯化钠增强T细胞代谢适应性和细胞毒性

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SCI 16 September 2024 Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity (Nature Immunology, IF: 27.7) Dominik Soll, Chang-Feng Chu, Shan Sun, Veronika Lutz, Mahima Arunkumar, Mariam Gachechiladze, Sascha Sch.uble, Maha Alissa-Alkhalaf, Trang Nguyen, Michelle-Amirah Khalil8, Ignacio Garcia-Ribelles2, Michael Mueller2, Katrin Buder9, Bernhard Michalke10, Gianni Panagiotou4,11, Kai Ziegler-Martin12, Pascal Benz12, Philipp Schatzlmaier13, Karsten Hiller8, Hannes Stockinger13, Maik Luu12, Kilian Schober14,15, Carolin Moosmann14, Wolfgang W. Schamel5,6, Magdalena Huber3 & Christina E. Zielinski CORRESPONDENCE TO：christina.zielinski@uni-jena.de The efficacy of antitumor immunity is associated with the metabolic state of cytotoxic T cells, which is sensitive to the tumor microenvironment. Whether ionic signals affect adaptive antitumor immune responses is unclear. In the present study, we show that there is an enrichment of sodium in solid tum ………………………………