GNAS变异对实体瘤的分子和临床病理影响

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SCI 1 September 2024 Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors （IF: J Clin Oncol., 42.1） Johannet P, Abdelfattah S, Wilde C, Patel S, Walch H, Rousseau B, Argiles G, Artz O, Patel M, Arfe A, Cercek A, Yaeger R, Ganesh K, Schultz N, Diaz LA, Foote MB. Molecular and Clinicopathologic Impact of GNAS Variants Across Solid Tumors. J Clin Oncol. 2024 Aug 9:JCO2400186.  CORRESPONDING AUTHOR：Michael B. Foote, MD; Twitter: @MikeFooteMD; e-mail: footem@mskcc.org. PURPOSE 目的 The molecular drivers underlying mucinous tumor pathogenicity are poorly understood. GNAS mutations predict metastatic burden and treatment resistance in mucinous appendiceal adenocarcinoma. We investigated the pan-cancer clinicopathologic relevance of GNAS variants.  粘液性肿瘤的致病分子机制尚不明确。GNAS突变可预测粘液性阑尾腺癌的转移负荷和治疗耐药性。我们研究了GNAS变异在泛癌种中的临床病理相关性。 METHODS 方法 We a ………………………………