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英文音频来自 NEJM官网 nejm.org 1 替尔泊肽治疗代谢功能障碍相关脂肪性肝炎合并肝纤维化 Tirzepatide for Metabolic Dysfunction–Associated Steatohepatitis with Liver Fibrosis 摘 要 背景 代谢功能障碍相关脂肪性肝炎(MASH)是一种与肝脏相关并发症和死亡相关的进行性肝病。替尔泊肽是葡萄糖依赖性促胰岛素多肽和胰高血糖素样肽-1受体激动剂,其对MASH合并中度或重度纤维化患者的疗效和安全性尚不明确。 Background Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive liver disease associated with liver-related complications and death. The efficacy and safety of tirzepatide, an agonist of the glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, in patients with MASH and moderate or severe fibrosis is unclear. 方法 我们对活检确诊MASH合并F2或F3期(
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