Journal of Medicinal Chemistry，2024年67卷8期先导化合物

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Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death Reducing PD-L1 Expression by Degraders and Downregulators as a Novel Strategy to Target the PD-1/PD-L1 Pathway Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with  MTAP -Deleted Cancers Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors Synthesis and Structure–Activity Relationships for Glutamate Transporter Allosteric Modulators Synthesis and Structure–Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Lo ………………………………