表观基因组异质性是肿瘤进化的来源

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SCI 8 November 2024 Epigenomic heterogeneity as a source of tumour evolution (Nature Reviews Cancer, IF: 72.5) Marthe Laisné, Mathieu Lupien & Céline Vallot CORRESPONDENCE TO: mathieu.lupien@uhn.ca; celine.vallot@curie.fr Abstract 摘要 In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target DNA sequence variants. However, a purely genetic approach to treatment selection is hampered by the fact that diverse cell states can emerge from the same genotype. In multicellular organisms, cell-state heterogeneity is driven by epigenetic processes that regulate DNA-based functions such as transcription; disruption of these processes is a hallmark of cancer that enables the emergence of defective cell states. Advances in single-cell technologies have unlocked our ability to quantify the epigenomic heterogeneity of tumours and understand its mechanisms, thereby transforming our appreciation of how epigenomic changes drive can ………………………………