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Francesco Passiglia, Antonio Russo Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy Correspondence to： Antonio Russo, MD, PhD.Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Via del Vespro 129 – 90127, Palermo, Italy.Email:antonio.russo@usa.net. Provenanc ：This is an invited Editorial commissioned by Section Editor Shaohua Cui (Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China). Comment on ：Cheng Y, Murakami H, Yang PC, et al.Randomized Phase II Trial of Gefitinib With and Without Pemetrexed as First-Line Therapy in Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer With Activating Epidermal Growth Factor Receptor Mutations.J Clin Oncol 2016;34:3258-66 Submitted Dec 01, 2016.A
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