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SCI 2 August 2024 Targeting chromosomal instability in patients with cancer (Nature Reviews Clinical Oncology, IF: 81.1) Duaa H. Al-Rawi1, Emanuele Lettera, Jun Li1, Melody DiBona & Samuel F. Bakhoum CORRESPONDENCE TO: samuel.bakhoum@gmail.com Abstract 摘要 Chromosomal instability (CIN) is a hallmark of cancer and a driver of metastatic dissemination, therapeutic resistance, and immune evasion. CIN is present in 60–80% of human cancers and poses a formidable therapeutic challenge as evidenced by the lack of clinically approved drugs that directly target CIN. This limitation in part reflects a lack of well-defined druggable targets as well as a dearth of tractable biomarkers enabling direct assessment and quantification of CIN in patients with cancer. Over the past decade, however, our understanding of the cellular mechanisms and consequences of CIN has greatly expanded, revealing novel therapeutic strategies for the treatment of chromosomally unstable tumours as well as new met
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