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REPORT 1 ✦ ✦ ✦ Laboratory Chemistry in a Protein… within a Cell…for Artificial Biosynthesis The introduction of functional groups at the positions of typically unreactive C-H bonds site-selectively and the stereo- and regio-selective functionalization of unconjugated C=C bonds have been longstanding challenges in catalysis. To this end, our group has been motivated by the limits of small-molecule catalysts for such reactions to begin to investigate artificial metalloenzymes. These artificial metalloenzymes contain synthetic cofactors possessing abiotic metal centers that catalyze unnatural reactions with control over selectivity resulting from the protein environment. In the best-case scenario such reactions could occur within the cells of E. coli or other microorganisms and in the long-term to occur as part of an unnatural biosynthetic pathway to produce unnatural products by fermentation. This talk will include results on new transformations, new mechanisms, new reacti
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