人体类器官的临床应用

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SCI 19 February 2025 Clinical applications of human organoids (Nat Med, IF: 58.7) Verstegen MMA, Coppes RP, Beghin A, et al: Clinical applications of human organoids. Nat Med 31:409–421, 2025 Organoids are innovative three-dimensional and self-organizing cell cultures of various lineages that can be used to study diverse tissues and organs. Human organoids have dramatically increased our understanding of developmental and disease biology. They provide a patient-specific model to study known diseases, with advantages over animal models, and can also provide insights into emerging and future health threats related to climate change, zoonotic infections, environmental pollutants or even microgravity during space exploration. Furthermore, organoids show potential for regenerative cell therapies and organ transplantation. Still, several challenges for broad clinical application remain, including inefficiencies in initiation and expansion, increasing model complexity and difficulties with ………………………………