癌症中的树突状细胞成熟

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SCI 22 February 2025 Dendritic cell maturation in cancer (Nature Reviews Cancer, IF: 72.5) Chang Yoon Moon, Meriem Belabed, Matthew D. Park, Raphaël Mattiuz, Daniel Puleston & Miriam Merad CORRESPONDENCE TO: miriam.merad@mssm.edu Abstract 摘要 Dendritic cells (DCs) are specialized antigen-presenting cells that are present at low abundance in the circulation and tissues; they serve as crucial immune sentinels by continually sampling their environment, migrating to secondary lymphoid organs and shaping adaptive immune responses through antigen presentation. Owing to their ability to orchestrate tolerogenic or immunogenic responses to a specific antigen, DCs have a pivotal role in antitumour immunity and the response to immune checkpoint blockade and other immunotherapeutic approaches. The multifaceted functions of DCs are acquired through a complex, multistage process called maturation. Although the role of inflammatory triggers in driving DC maturation was established decades ago, ………………………………