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突变型IDH1抑制诱导dsDNA感应激活肿瘤免疫

SCI天天读  · 公众号  ·  · 2024-08-11 20:00
    

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SCI 11 August 2024 Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity (Science;IF:44.7) Wu MJ, Kondo H, Kammula AV, Shi L, Xiao Y, Dhiab S, Xu Q, Slater CJ, Avila OI, Merritt J, Kato H, Kattel P, Sussman J, Gritti I, Eccleston J, Sun Y, Cho HM, Olander K, Katsuda T, Shi DD, Savani MR, Smith BC, Cleary JM, Mostoslavsky R, Vijay V, Kitagawa Y, Wakimoto H, Jenkins RW, Yates KB, Paik J, Tassinari A, Saatcioglu DH, Tron AE, Haas W, Cahill D, McBrayer SK, Manguso RT, Bardeesy N. Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity. Science. 2024 Jul 12;385(6705):eadl6173. doi: 10.1126/science.adl6173. Epub 2024 Jul 12. PMID: 38991060. Corresponding authors:Robert T. Manguso, Krantz Family Center for Cancer Research, Massachusetts,General Hospital, Boston MA, USA.,Email: rmanguso@broadinstitute.org,Nabeel Bardeesy, Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston MA, USA.Email: bardeesy.nabeel@mgh.harvard.edu (N. ………………………………

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