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SCI 27 March 2025 Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33 (Cancer Cell, IF: 48.8) Sara Lamorte, Rene Quevedo, Robbie Jin, Luke Neufeld, Zhe Qi Liu, M. Teresa Ciudad, Sabelo Lukhele, Jessica Bruce, Shreya Mishra, Xin Zhang, Zaid Kamil Saeed, Hal Berman, Dana J. Philpott, Stephen E. Girardin, Shane Harding, David H. Munn, Tak W. Mak, Mikael C.I. Karlsson, David G. Brooks, and Tracy L. McGaha CORRESPONDENCE TO: tracy.mcgaha@uhn.ca SUMMARY 摘要 Apoptotic cells are immunosuppressive, creating a barrier in cancer treatment. Thus, we investigated immune responses to dying tumor cells after therapy in the tumor draining lymph node (TDLN). A key population responsible for clearing tumor material in the TDLN was medullary sinus macrophages (MSMs). Tumor debris phagocytosis by MSMs induces the cytokine IL-33, and blocking the IL-33 receptor (ST2) or deletion of Il33 in MSMs enhances therapy responses.
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