文章预览
SCI 4 September 2024 The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma (Cancer Discov, IF: 29.7) Wang S, Zeng Y, Zhu L, et al: The N6-methyladenosine Epitranscriptomic Landscape of Lung Adenocarcinoma. Cancer Discov 10.1158/2159-8290.CD-23–1212, 2024 Abstract Comprehensive m6A epitranscriptome profiling of primary tumors remains largely uncharted. Here, we profiled the m6A epitranscriptome of 10 non-neoplastic lung (NL) tissues and 51 lung adenocarcinoma (LUAD) tumors, integrating the corresponding transcriptome, proteome and extensive clinical annotations. We identified distinct clusters and genes that were exclusively linked to disease progression through m6A modifications. In comparison with NL tissues, we identified 430 transcripts to be hypo-methylated and 222 to be hyper-methylated in tumors. Among these genes, EML4 emerged as a novel metastatic driver, displaying significant hyper-methylation in tumors. m6A modification promoted the translation of E
………………………………
