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文|小药怪 NEJM：Deucravacitinib ph2 data best data 12 mg qd PASI75 75% 自己ph2和别人ph3比较，就是ph2之间比较，本也是不ok的，关注公众号久的老读者应该不陌生笔者这句话，过去文章说很多次了， 数值看看得了，不怕较真，也不怕承认错误，错了就错，改就是。 Background: Tyrosine kinase 2 (TYK2) signaling pathways, which mediate cytokine signaling, are implicated in the pathophysiology of psoriasis. Selective inhibitors of TYK2 may be effective in treating psoriasis.（ N Engl J Med. 2018 Oct 4;379(14):1313-1321. ） Methods: We conducted a phase 2, double-blind trial of a TYK2 inhibitor, BMS-986165, in adults with moderate-to-severe psoriasis, excluding patients with a previous lack of response to agents targeting cytokine signaling through the same tyrosine kinase pathway. Patients were randomly assigned to receive the drug orally at a dose of 3 mg every other day, 3 mg daily, 3 mg twice daily, 6 mg twice dail
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