文章预览
SCI 20 September 2024 DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism (Nat Med, IF: 58.7) Jee J, Brannon AR, Singh R, et al: DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism. Nat Med 30:2499–2507, 2024 Abstract 摘要 Cancer-associated venous thromboembolism (VTE) is a major source of oncologic cost, morbidity and mortality. Identifying high-risk patients for prophylactic anticoagulation is challenging and adds to clinician burden. Circulating tumor DNA (ctDNA) sequencing assays ('liquid biopsies') are widely implemented, but their utility for VTE prognostication is unknown. Here we analyzed three plasma sequencing cohorts: a pan-cancer discovery cohort of 4,141 patients with non-small cell lung cancer (NSCLC) or breast, pancreatic and other cancers; a prospective validation cohort consisting of 1,426 patients with the same cancer types; and an international generalizability cohort of 463 patients with advanced NSCLC. ct
………………………………
