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药学 Pharmacological Research Targeting the Gut Microbiota to Mitigate Health Disorders 全文截稿: 2024-08-31 影响因子: 5.893 CCF分类: 无 中科院JCR分区: • 小类 : 医学 - 2区 • 小类 : 药学 - 2区 网址: https://www.journals.elsevier.com/pharmacological-research/ Gut microbes play an immense role in digesting ingested food, providing nutrients to the host, and producing several bioactive metabolites that not only help maintain health but can also elicit disease during dysbiotic conditions. The bioactive compounds derived from gut microbiota metabolites include trimethylamine-N-oxide (TMAO), uremic toxins, short chain fatty acids (SCFAs), phytoestrogens, anthocyanins, bile acids, lipopolysaccharide – to name a few. Once these compounds enter the host cells, tissues, and organs they can cause diseases such as epigenetic, metabolic, neurodegenerative, psychiatric, cardiovascular, hypertension, respiratory, gastrointestinal, kidney, bone, cancer, a
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