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SCI 30 August 2024 Tertiary lymphoid structures in anticancer immunity (Nature Reviews Cancer, IF: 72.5) Jean-Luc Teillaud, Ana Houel, Marylou Panouillot, Clémence Riffard & Marie-Caroline Dieu-Nosjean CORRESPONDENCE TO: marie-caroline.dieu-nosjean@inserm.fr Abstract 摘要 Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where adaptive antitumour cellular and humoral responses can be elaborated. Initially described in non-small cell lung cancer as functional immune lymphoid structures associated with better clinical outcome, TLS have also been found in many other carcinomas, as well as melanomas and sarcomas, and associated with improved response to immunotherapy. The manipulation of TLS as a therapeutic strategy is now coming of age owing to the likely role of TLS in the improved survival of patients with cancer receiving immune checkpoint inhibitor treatment. TLS have also garnered considerable interest as a predictive biomarker of the response to an
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