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研究内容简介 Visual representation of
starvation-immunotherapy enabled by ASNase-ELP in conjunction with aPD-1. (a)
The biosynthetic route of ASNase-ELP, wherein AlphaFold2 predicted the structures
of ELP, ASNase, and ASNase-ELP. (b) Enhanced anti-metastatic efficacy of
starvation-immunotherapy. ASNase-ELP precipitates out to form a reservoir upon
intratumoral injection. The sustained dissolution of ASNase-ELP in the
reservoir leads to its durable diffusion into the tumor tissue and the
circulatory system. The activ e form of ASNase-ELP efficiently catabolizes Asn,
selectively inducing the death of tumor cells. Concurrently, aPD-1 blocks the
binding of PD-1 to its corresponding receptor, PD-L1, and facilitates the
recognition of major histocompatibility complex class I (MHC-I) molecules by
the T-cell receptor (TCR). Consequently, aPD-1 activation elicits a robust
immune response against the tumor cells, which works with the starvation mechanism
to enhance anti-metastatic effectiv
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