文章预览
SCI 22 September 2024 Fate induction in CD8 CAR T cells through asymmetric cell division （IF: Nature, 50.5） Lee CS, Chen S, Berry CT, Kelly AR, Herman PJ, Oh S, O'Connor RS, Payne AS, Ellebrecht CT. Fate induction in CD8 CAR T cells through asymmetric cell division. Nature. 2024 Sep;633(8030):670-677. Correspondence:e-mail: asp2261@cumc.columbia.edu; chell@pennmedicine.upenn.edu Early expansion and long-term persistence predict efficacy of chimeric antigen receptor T cells (CARTs)1–7, but mechanisms governing effector versus memory CART differentiation and whether asymmetric cell division induces differential fates in human CARTs remain unclear. Here we show that target-induced proximity labelling enables isolation of first-division proximal-daughter and distal-daughter CD8 CARTs that asymmetrically distribute their surface proteome and transcriptome, resulting in divergent fates. Target-engaged CARs remain on proximal daughters, which inherit a surface proteome resembling acti
………………………………
