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SCI 2 September 2024 Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity （Nature immunology；IF：27.7） Santollani L, Maiorino L, Zhang YJ, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Walsh AA, Wittrup KD, Irvine DJ. Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity. Nat Immunol. 2024 Aug 7. doi: 10.1038/s41590-024-01925-7. Epub ahead of print. PMID: 39112631. Corresponding author: K. Dane Wittrup, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. e-mail: wittrup@mit.edu Darrell J. Irvine, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. e-mail: djirvine@mit.edu Abstract 摘要 Systemically administered cytokines are potent immunotherapeutics but can cause severe dose-limiting toxicities. To overcome this challenge, cytokines have been engineered
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