组蛋白基因上的RNA聚合II可预测人类癌症的结局

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SCI 1 February 2025 RNA polymerase II at histone genes predicts outcome in human cancer （Science; IF:44.8） Henikoff S, Zheng Y, Paranal RM, Xu Y, Greene JE, Henikoff JG, et al. RNA polymerase II at histone genes predicts outcome in human cancer. Science. 2025;387:737-43. Correspondence to：steveh@fredhutch.org Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cleavage under targeted accessible chromatin method for mapping RNA polymerase II (RNAPII) genome-wide in FFPE sections. We demonstrate global RNAPII elevations in mouse gliomas and assorted human tumors in small clinical samples and discover regional elevations corresponding to de novo HER2 amplifications punctuated by likely selective sweeps. RNAPII occupancy at S-phasedependent histone genes correlated with WHO grade in meningiomas, accurately predicted rapid recurrence, and ………………………………