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SCI 9 August 2024 Mammalian SWI/SNF complex activity regulate POU2F3 and constitutes a targetable dependency in small cell lung cancer (Cancer Cell, IF: 48.8) Leslie Duplaquet, Kevin So, Alexander W. Ying, Shreoshi Pal Choudhuri, Xinyue Li, Grace D. Xu, Yixiang Li, Xintao Qiu, Rong Li, Shilpa Singh, Xiaoli S. Wu, Seth Hamilton, Victor D. Chien, Qi Liu, Jun Qi, Tim D.D. Somerville, Hillary M. Heiling, Emanuele Mazzola, Yenarae Lee, Thomas Zoller, Christopher R. Vakoc, John G. Doench William C. Forrester, Tinya Abrams, Henry W. Long, Matthew J. Niederst, Benjamin J. Drapkin, Cigall Kadoch, and Matthew G. Oser CORRESPONDENCE To: cigall_kadoch@dfci.harvard.edu, matthew_oser@dfci.harvard.edu SUMMARY 摘要 Small cell lung cancers (SCLCs) are composed of heterogeneous subtypes marked by lineage-specific transcription factors, including ASCL1, NEUROD1, and POU2F3. POU2F3-positive SCLCs, 12% of all cases, are uniquely dependent on POU2F3 itself; as such, approaches to attenuate POU2F3 exp
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