纳武利尤单抗免疫治疗期间新抗原免疫原性格局和肿瘤生态系统的演变

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SCI 18 October 2024 Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab (Nature Medicine, IF: 58.7) Tyler J. Alban, Nadeem Riaz, Prerana Parthasarathy, Vladimir Makarov, Sviatoslav Kendall, Seong-Keun Yoo, Rachna Shah, Nils Weinhold, Raghvendra Srivastava, Xiaoxiao Ma, Chirag Krishna, Juk Yee Mok, Wim J. E. van Esch, Edward Garon, Wallace Akerley, Benjamin Creelan, Nivedita Aanur, Diego Chowell, William J. Geese, Naiyer A. Rizvi & Timothy A. Chan CORRESPONDENCE TO: chant2@CCF.org Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes treatment response remain poorly understood. To address these questions, 80 patients with non-small cell lung cancer were enrolled in the biomarker cohort of CheckMate 153 (CA209-153), which collected radiographic guided biopsy samples before treatment and during treatment with nivolumab. Early loss of m ………………………………