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SCI 13 November 2024 Prediction of brain metastasis development with DNA methylation signatures (Nature Medicine, IF: 58.7) Jeffrey A. Zuccato, Yasin Mamatjan, Farshad Nassiri, Andrew Ajisebutu, Jeffrey C. Liu, Ammara Muazzam, Olivia Singh, Wen Zhang, Mathew Voisin, Shideh Mirhadi, Suganth Suppiah, Leanne Wybenga-Groot, Alireza Tajik, Craig Simpson, Olli Saarela, Ming S. Tsao, Thomas Kislinger, Kenneth D. Aldape, Michael F. Moran, Vikas Patil & Gelareh Zadeh CORRESPONDENCE TO: vikas.patil@uhn.ca; gelareh.zadeh@uhn.ca Brain metastases (BMs) are the most common and among the deadliest brain tumors. Currently, there are no reliable predictors of BM development from primary cancer, which limits early intervention. Lung adenocarcinoma (LUAD) is the most common BM source and here we obtained 402 tumor and plasma samples from a large cohort of patients with LUAD with or without BM (n = 346). LUAD DNA methylation signatures were evaluated to build and validate an accurate model predicting BM
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