肝毒性作为限制免疫检查点抑制剂使用增加的因素

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SCI 26 September 2024 Liver toxicity as a limiting factor to the increasing use of immune checkpoint inhibitors (JHEP Reports, IF: 9.5) Eleonora De Martin, Jean-Marie Michot, Olivier Rosmorduc, Catherine Guettier, Didier Samuel CORRESPONDENCE TO: eleonora.demartin@aphp.fr Summary 摘要 Immune checkpoint inhibitors (ICIs) improve clinical outcomes in patients suffering from different types of cancer. Liver toxicity is one of the immune-related adverse events associated with immunotherapy; although not common, its management is challenging as it is extremely heterogeneous in terms of presentation and severity. Differences in the development and evolution of ICI-related toxicity in healthy or cirrhotic livers have not yet been elucidated. Assessing causality is key to diagnosing ICI-induced liver toxicity; liver biopsies can assist not only in the differential diagnosis but also in assessing the severity of histological liver damage. The current classification of severity overestimates ………………………………