上呼吸消化道鳞状细胞癌：生物学、遗传学和治疗的统一观点

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SCI 27 February 2025 Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy  (Cancer Cell, IF: 48.8) Henick BS, Taylor AM, Nakagawa H, et al: Squamous cell cancers of the aero-upper digestive tract: A unified perspective on biology, genetics, and therapy.  Cancer Cell 43:178–194, 2025 Squamous cell cancers (SCCs) of the head and neck, esophagus, and lung, referred to as aero-upper digestive SCCs, are prevalent in the United States and worldwide. Their incidence and mortality are projected to increase at alarming rates, posing diagnostic, prognostic, and therapeutic challenges. These SCCs share certain epigenetic, genomic, and genetic alterations, immunologic properties, environmental exposures, as well as lifestyle and nutritional risk factors, which may underscore common complex gene-environmental interactions across them. This review focuses upon the frequent shared epigenetic, genomic, and genetic alterations, emerging pr ………………………………