CAF诱导的物理限制控制实体瘤中T细胞的状态和定位

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SCI 7 October 2024 CAF-induced physical constraints controlling T cell state and localization in solid tumours (IF: Nat Rev Cancer., 72.5) Arpinati L, Carradori G, Scherz-Shouval R. CAF-induced physical constraints controlling T cell state and localization in solid tumours. Nat Rev Cancer. 2024 Oct;24(10):676-693. Correspondence: ruth.shouval@ weizmann.ac.il Solid tumours comprise cancer cells that engage in continuous interactions with non-malignant cells and with acellular components, forming the tumour microenvironment (TME). The TME has crucial and diverse roles in tumour progression and metastasis, and substantial efforts have been dedicated into understanding the functions of different cell types within the TME. These efforts highlighted the importance of non-cell autonomous signalling in cancer, mediating interactions between the cancer cells, the immune microenvironment and the non-immune stroma. Much of this non-cell-autonomous signalling is mediated through acellular componen ………………………………