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SCI 19 October 2024 Molecular imaging supports the development of multispecific cancer antibodies (Nature Reviews Clinical Oncology, IF: 81.1) Claudia A. J. van Winkel, Frank R. Pierik, Adrienne H. Brouwers, Derk Jan A. de Groot, Elisabeth G. E. de Vries & Marjolijn N. Lub-de Hooge CORRESPONDENCE TO: m.n.de.hooge@umcg.nl Abstract 摘要 Multispecific antibodies are engineered antibody derivatives that can bind to two or more distinct epitopes or antigens. Unlike mixtures of monospecific antibodies, the binding properties of multispecific antibodies enable two specific molecules to be physically linked, a characteristic with important applications in cancer therapy. The field of multispecific antibodies is highly dynamic and expanding rapidly; to date, 15 multispecific antibodies have been approved for clinical use, of which 11 were approved for oncological indications, and more than 100 new antibodies are currently in clinical development. Nevertheless, substantial challenges limit
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