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点击上方 蓝字 关注我们 10-hydroxy-2-decenoic acid prevents
osteoarthritis by targeting aspartyl β hydroxylase
and inhibiting chondrocyte senescence in male mice preclinically 作者 ： Nana Geng,
Mengtian Fan, Biao Kuang, Fengmei Zhang, Menglin Xian, Lin Deng, Cheng Chen,
Yiming Pan, Jianqiang Chen, Naibo Feng, Li Liang, Yuanlan Ye, Kaiwen Liu,
Xiaoli Li, Yu Du, Fengjin Guo (State Key
Laboratory of Ultrasound in Medicine and Engineering, School of Basic Medical
Sciences, The Second Affiliated Hospital of Chongqing Medical University,
Chongqing Medical University, Chongqing, China.) 发表情况 ： Nat Commun . 2024 Sep 4;15(1):7712. DOI: 10.1038/s41467-024-51746-3. 科学问题 细胞衰老已经被广泛认为是影响关节组织稳态和加重OA进展的重要因素。而已经有研究表明，10-羟基-2-癸烯酸（10-HDA）是一种独特的中链脂肪酸，能抑制UVA诱导的细胞衰老和活性氧（ROS）生成。因此本研究探究了10-HDA是否能够
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